Nolvadex - is a nonsteroidal antiestrogen. First of all it is used as an antineoplastic medicine used for treating breast and endometrium cancer. It is also used for treating kidney cancer, soft tissue sarcoma, prostatic carcinoma, melanoma (in combination with radiation therapy and cytostatics) and induction of ovulation in patients with anovulatory infertility.
How Nolvadex works?
Nolvadex is a synthetical triphenylethylene derivative which is a nonsteroidal antiestrogen. The apparent nonsteroidal properties of the medicine are associated with its ability to prevent absorption of estrogens in specific parts of target organ receptors, probably through binding with estrogen receptors. Nolvadex inhibits autospecific estrogen receptors and thus hampers tumor progression stimulated byu estrogens. It has been proved that Nolvadex has estrogen-like influence on a number of systems in human body including endometrium, bones and blood lipids.
What is Nolvadex for?
Breast and endometrium cancer. Palliative therapy of neglected breast cancer in menopausal women and in post-surgery period as an adjuvant hormonal therapy. Also used for treating kidney cancer, soft tissue sarcoma Possible uses of Nolvadex may include metastazing prostatic carcinoma (in case of resistance to other medicines), therapy of melanosis containing estrogen receptors and as ovulation inductionin case of anovulatory infertility. Nolvadex could abe used in combination with radiation therapy and cytostatic agents.
How to take Nolvadex?
The dosage of Nolvadex is detrmined individually. It is a peroral drug taken once or twice a day with some water. The average starting dose of Nolvadex is 10 mg 2-3 times a day; this dose could be increased to 10-20mg three times a day. The dose of 30-60 mg/day (which is reached gradually) could be used during one month. The duration of the therapy may last 2-3 years.
What are contraindications for Nolvadex?
Nolvadex is contraindicated in the period before menopause and during pregnancy; increased sensitivity to any ingredient in Nolvadex; pregnancy and lactation (there have been few cases of spontaneous abortions, inborn defects and intrauterine fetal death after using the medicine, though theer is no direct evidence that they were caused by Nolvadex); Nolvadex should be used with caution in patients with renal pathologies, diabetes, ophthalmological diseases and inopectic disorders in past history. There is no exact information whether Nolvadex is found in breast milk, that is why it is not recommended during breast-feeding period. The decision about stopping breastfeeding and starting Nolvadex should be based on the importance of the medicine to mother's health.